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Another issue of interest to organizational management is software upgrades Software vendors revise their programs and sell new versions often The revised software may offer valuable enhancements, or, on the other hand, it may offer little in terms of additional capabilities Also, the revised software may contain bugs Deciding whether to purchase the newest software can be a problem for organizations and their IS managers It is also dif cult to decide whether to be one of the rst companies to buy and take strategic advantage of new software before competitors do, but risk falling prey to previously undiscovered bugs The concept of open systems refers to a model of computing products that work together Achieving this goal is possible through the use of the same operating system with compatible software on all the different computers that would interact with one another in an organization.

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A complementary approach is to produce application software that will run across all computer platforms If hardware, operating systems, and application software are designed as open systems, the user would be able to purchase the best software for the job without worrying whether it will run on particular hardware As an example, much Apple MacIntosh application software would not run on Wintel (Windows-Intel) PCs, and vice versa Neither of these would run on a mainframe Certain operating systems, like UNIX, will run on almost any machine Therefore, to achieve an open-systems goal, organizations frequently employ UNIX on their desktop and larger machines so that software designed for UNIX will operate on any machine Recent advances toward the open-systems goal involve using the Java language, which can be run on many types of computers, in place of a traditional operating system Open systems should not be confused with open source software.

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1612 Glycoproteins Proteins with covalently attached carbohydrate chains (oligosaccharides) are found on the outer surface of the plasma membrane of cells, as part of the extracellular matrix, and in the blood; indeed, except for albumin, nearly all of the proteins in plasma are glycoproteins Cell-associated glycoproteins include receptors (eg, the LDL receptor) and ion exchangers in membranes (eg, the chloride-bicarbonate exchanger known as band 3 of erythrocytes) Glycoproteins also play important roles in cell growth and development, and in the communication that occurs between cells A particular glycoprotein can have one or as many as 30 oligosaccharide chains, with the carbohydrate accounting for as little as 1% to as much as 70% of the mass of the glycoprotein.

Open source software is software made available in source code form at no cost to developers There are many examples of open-source software, including the GNU (GNU s Not UNIX) suite of software (gnuorg) developed by the Free Software Foundation (fsforg); the Linux operating system; Apache Web server (apache org); sendmail SMTP (Send Mail Transport Protocol) e-mail server (sendmailorg);.

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The oligosaccharide chains of a particular glycoprotein usually influence one or more of its biological properties, including intracellular transport, solubility, viscosity, susceptibility to inactivation (by heat, extremes of pH, and proteolysis), and the tendency to aggregate The carbohydrate chains of glycoproteins are grouped into two classes, depending on how they are linked to the protein 0-linked oligosaccharides are linked to protein through a glycosidic bond to the hydroxyl group of a threonine or serine residue, whereas N-linked oligosaccharides are attached to the amide nitrogen of an asparagine residue in the protein Many proteins, including the LDL receptor, contain both N- and 0-linked oligosaccharide domains Figure 16-5 illustrates two types of N-asparaginelinked oligosaccharide chains commonly found in mammalian glycoproteins: the high-mannose type and the complex type 76127 Mocins Mucins are a subclass of glycoproteins that are abundantly glycosylated.

Choose one artboard. One artboard is all you need. Think of artboards as pages of your document. For example, if you design a flyer with a front and back page in Illustrator, you set your artboards to two instead of one.

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They are high molecular weight (200 to 10,000 kDa) glycoproteins that contain dozens to several hundred oligosaccharides 0-linked to serine or threonine residues oligosaccharides usually account for 50 to 90% of the total mass of the mucin molecule The sugars that comprise a particular oligosaccharide chain of a mucin may include N-acetylgalactosamine (GalNAc), galactose (Gal), N-acetylglucosamine (GlcNAc), fucose, and sialic acid Secreted mucins (such as salivary mucin) aggregate into oligomeric gels which form a protective layer over the digestive, respiratory, and reproductive tracts and provide lubrication as well as a barrier against pathogens and toxins Other mucins are integral membrane proteins and remain cell-associated Cancer cells often synthesize abnormal mucins, whose structures can perturb the normal function of a cell, including its immunologic and adhesive properties and its potential to invade and metastasize..

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